Current issue

Advanced Nano-Bio-Materials and Devices – AdvNanoBioMD 2023; Vol 7; Issue 4 is now being populated. Thank you for all the contributors and reviewers!

Advanced Nano-Bio-Materals and Devices – AdvNanoBioMD 2023; Vol 7; Issue 4 (December 31)

Cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce antibacterial, anti-inflammatory and cytotoxic activities. The potential of cyanobacteria as anticancer agents has been the most explored and several compounds have emerged as templates for the development of new anticancer drugs. In the present paper a compilation of  cyanobacterial compounds with anticancer properties is presented and a potential local strain Nostoc halophilum Hansgirg ex Geitler is introduced.

This paper presents the important aspects of the field-effect transistors working as immunosensors, known as Immuno-FETs, their evolution in terms of technology, performances and some of their most significant applications. The gate of the immuno-transistor is enveloped with a distinct biological recognition element, such as an antibody, that seizes the desired target molecule. The existence or non-existence of the target molecule is ascertained through variations in the electrical signal that modify the charge within the FET channel. The effectiveness of Immuno-FETs has been consistently advancing and enhancing throughout the years, yet certain shortcomings have endured. Early Immuno-FETs employed polyclonal antibodies as recognition components, exhibiting poor selectivity and limited sensitivity. The progress in nanotechnology facilitated the impressive miniaturization of Immuno-FETs, leading to considerably diminished proportions. This decrease in size played a role in improved sensitivity and lowered limits of detection. These parameters were improved by the incorporation of innovative materials like graphene and carbon nanotubes. In general, the Immuno-FET’s performances are dictated by its specific technology that significantly improved, rendering them as suitable contenders for potential applications in domains such as environmental observation, nutrition hygiene, and healthcare examination.

Semiconductor transistors are increasingly being used in biosensors due to their ability to detect biological molecules with high sensitivity and selectivity. These biosensors typically operate based on the modulation of charge carrier transport through the transistor channel in response to the presence of a specific biological molecule, resulting in a measurable electrical signal. This approach offers several advantages over traditional sensing methods, including high sensitivity, selectivity, and real-time monitoring capabilities. This paper discusses an overview of the working principle, technology development, and performance development of transistors with organic semiconductor applied in biosensors, highlighting the potential of these devices in the development of novel flexible biosensing platforms for a large range of applications in the medical diagnostics, environmental monitoring, and food safety.