Egziabher H MICHAEL, Om Prakash YADAV, Tesfahun KEBEDE and Lokesh YADAV; Green Synthesis of Plant Leaf Extract Mediated Copper Nanoparticles and their Antimicrobial Activity; Advanced Nano-Bio-Materials and Devices; 2017:1(3):161-171

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Copper nanoparticles have been synthesized by the reduction of copper ions using plant leaf extracts of khat (Catha edulis), castor oil (Ricimus communis) and derjihara (Prosopis juliflora) as reducing and stabilizing agents. The progress of bio-reduction of Cu2+ ions generating metallic copper was monitored by observing the absorption peak around 566 nm, characteristic of surface plasma resonance of copper. The X-ray diffraction (XRD) analysis revealed the face centre cubic (fcc) crystal structure of synthesized copper nanoparticles with average crystallite size within 20 to 30nm. The FTIR spectra suggests that copper nanoparticles are stabilized possibly by proteins molecules present in the leaf extract. The synthesized copper nanoparticles have shown anti-microbial activity against both gram-negative, Escherichia coli, as well as gram-positive, Staphylococcus aureus bacteria. The synthesized copper nanoparticles may be tried, clinically, for their antibacterial, cytotoxic, and antibiofilm efficacy or may be used as copper nanoparticles-containing antimicrobial hydrogel membrane for the treatment of wounds.