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Advanced Nano-Bio-Materials and Devices – AdvNanoBioMD 2018; Vol 2; Issue 1

Advanced Nano-Bio-Materials and Devices – AdvNanoBioMD 2018; Vol 2; Issue 1

Highly-porous ceramics samples based on nanostructured biogenic hydroxyapatite and superfine fumed silica have been prepared using a foam replication method at a sintering temperature of 850°С. They were shown to possess a total porosity 86-89 % and a permeable open-porous (~ 90 % of the total porosity) structure with pore sizes in the range 500-1000 μm. The compression strength is equal to 0.3-0.4 МPа. According to the XRD analysis it was established that during sintering hydroxyapatite phase remains, which was also confirmed by IR spectroscopy data. The carried out studies in vitro (the dissolution rate in saline) of the obtained highly-porous bioceramics showed that the samples are resorbable and their dissolution rate increases with growing porosity and decreasing HA content. Evaluation of adsorption activity (by the example of antibiotic Ceftriaxon) demonstrated prospectivity of ceramics as carriers of drugs for acceleration of patients’ post surgery rehabilitation in orthopedic, traumatic and dentistry surgery.

Gold coated mesoporous silica magnetic nanocomposite (mSiO2@Fe3O4 @Au) was synthesized using ethylene glycol (EG) as template at two different ratios of EG: TEOS of 0.1 and 0.6. The chemistry, morphology, optical and magnetic properties of the obtained nanocomposites were characterized by Fourier Transform (FTIR), Scanning Electron Microscopy (SEM), Transverse Electron Microscopy (TEM), Atomic Force Microscopy (AFM), X-ray Diffractometry (XRD), Vibrating Sample Magnetometry (VSM) and UV-Vis absorption spectroscopy. The mean diameter of amino-functionalized SiO2 NPs was measured 70 nm. The range of porosity ranged from 10 to 100 nm, with larger distribution of pore size of less than 20 nm. The average radius of pores on SiO2 NPs calculated by BJH method is approximately 15.5 nm. Magnetic nanoparticles (MNPs) with the average diameter of 34 nm were synthesized and then coated by AuNPs with an average size of 25 nm synthesized via a two-step process of dative and reduction method. The average size distribution of mSiO2@Fe3O4@Au nanocomposite was measured about 157 nm. The nanocomposite exhibited a significant red-shift in surface plasmon resonance wavelength (λSPR ≈ 800 nm), which coincides with NIR biomedical applications.