Cristina DAVID, Irina FIERĂSCU, Radu Claudiu FIERĂSCU, Constantin Cosmin BACIU, Denisa FICAI, Anton FICAI. Mesoporous silica platforms as potential support for antibiotics. Advanced Nano-Bio-Materials and Devices; 2020:4(4):645-654.
The age of porous materials started in 1992 along with the first synthesis of the MCM-41. During these ~ 30 years many synthesis routes were proposed and consequently, some characteristic mesoporous materials were developed and tested in many applications, including tissue engineering and drug delivery. This paper is highlighting the possibility to use mesoporous silica as platforms for the delivery of the antibiotics. It is based on a literature review of the drug delivery systems based on ordered mesoporous silica supports loaded with antibiotics and designed for the treatment of different infections. The manuscript is focused on the influence of pore size and surface functionalization on the final performances of these drug delivery systems being known that specific surface area and hydrophyl/hydrophobe ratio are among the most important factors influencing the interaction between the silica support and the antibiotic (drug).