Some places are very sensitive to pandemic mass transmission, where a contagious person can easily infect over 50 persons in only 2 minutes of exposure. Facing this pandemic, infrastructure is prone to cascading if appropriate protection measures are not implemented in advance. The novel COVID-19 has some features that put it in the class of nano-bio-robot, and in the class of bio-warfare agents, where an accurate understanding on its propagation means is needed in order to design and implement the most appropriate protection measures. Leaders have to be aware how to increase protection in places where social distancing is difficult to achieve, and in places favoring accumulation of hazardous aerosols. As a compressible bio-nanoparticle with dimensions between 60-140 nm COVID-19 is not retained by normal dry filtration systems conceived for clean rooms, and special measures have to be taken to increase protection, and prevent virus reproduction rate bigger than 1. It is also stated that a single measure is not enough, as “social distancing” did not work well in the US, and an assembly of measures applied in harmony has to be set in place, in order to stop virus propagation. More medical studies are needed in order to better understand the virus, its propagation and consequences of getting infected, where the concept of heard immunity is just wishful thinking driving towards a crippled society.