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Rayasa RAMACHANDRA RAO, Loganathan MARIAPPAN; Synthesis of Nanohydroxyapatite and Hydroxyapatite - Polycaprolactone Composite; Advanced Nano-Bio-Materials and Devices; 2017:1(2):86-98
Hydroxyapatite (HAp) - polycaprolactone (PCL) composite has found enhanced interest as scaffold material for bone tissue engineering application. The HAp phase is bioactive and provide the favorable environment for cell adhesion, proliferation, differentiation and cell conduction whereas the biodegradable PCL provide the required flexibility, mouldability and resorbability. Nanoparticles of HAp has been synthesized by precipitation method from Ca(NO3)2.4H2O and H3PO4 as precursors of Ca and P using tetrahydrofuran (THF) as the medium. The powder prepared was characterized for phase purity, functional group, particle size, surface area and morphology in comparison with the powder prepared using deionised water as the medium. By following the similar procedure of precipitation, nanoHAp was prepared in the PCL matrix with HAp to PCL ratio of 80:20 by wt % and HAp-PCL composite powder was filtered, dried at <50°C and characterized. The synthesized HAp and HAp-PCL composite show nano sized primary particles having X-ray pure hydroxyapatite phase. The HAp-PCL composite having homogeneous distribution of nanoHAp particles in PCL matrix could be a potential scaffold material for tissue engineering applications.