In early 1980-s, researchers discovered self-setting calcium orthophosphate (CaPO4) formulations (initially known as calcium phosphate cements), which were bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases formed pastes of variable viscosity, which set and hardened forming most commonly a bone-like non-stoichiometric calcium deficient hydroxyapatite (CDHA) […]