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Mohammad E. Khosroshahi and Maral Asemani; Synthesis and Characterization of Hydrogel-based Ferroscaffold Containing Fluorescein Isothiocyanate (FITC) Surface Modified Magnetite Nanoparticles as Optical Marker; Advanced Nano-Bio-Materials and Devices; 2017:1(3):146-160
Porous ferroscaffolds have interesting applications in bioengineering such as tissue engineering, controlled drug release and bioimaging. In this work, the conjugated fluorescein isothiocyanate (FITC) magnetite (Fe3O4) nanoparticles (FMNP) were embedded in the hydrogel scaffold (FFS) to study the effect of static magnetic field on swelling for drug release purpose as well as to serve as an optical marker to monitor visually the swelling of FFS for bioimaging. FFS was characterized using transmission electron microscopy (TEM), x-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), vibration scanning magnetometry (VSM), UV-VIS absorption spectroscopy and laser-induced fluorescence spectroscopy (LIFS). The LIF exhibited a loss of fluorescence intensity of about 11% and 18% corresponding to laser irradiation time of 10 and 30 s respectively due to quencher fluorescent molecule complex formation. The magnetoelasticity of FFS was studied using He-Ne laser probe beam-magnet experiment. The swelling factor was found to be relatively small, nonetheless it was visually observable due to argon laser-induced fluorescence.