Current issue

Advanced Nano-Bio-Materials and Devices – AdvNanoBioMD 2018; Vol 2; Issue 1 is now released. Thank you for all the contributors and reviewers!

Advanced Nano-Bio-Materials and Devices – AdvNanoBioMD 2018; Vol 2; Issue 1

Advanced Nano-Bio-Materials and Devices – AdvNanoBioMD 2018; Vol 2; Issue 1

Highly-porous ceramics samples based on nanostructured biogenic hydroxyapatite and superfine fumed silica have been prepared using a foam replication method at a sintering temperature of 850°С. They were shown to possess a total porosity 86-89 % and a permeable open-porous (~ 90 % of the total porosity) structure with pore sizes in the range 500-1000 μm. The compression strength is equal to 0.3-0.4 МPа. According to the XRD analysis it was established that during sintering hydroxyapatite phase remains, which was also confirmed by IR spectroscopy data. The carried out studies in vitro (the dissolution rate in saline) of the obtained highly-porous bioceramics showed that the samples are resorbable and their dissolution rate increases with growing porosity and decreasing HA content. Evaluation of adsorption activity (by the example of antibiotic Ceftriaxon) demonstrated prospectivity of ceramics as carriers of drugs for acceleration of patients’ post surgery rehabilitation in orthopedic, traumatic and dentistry surgery.

Gold coated mesoporous silica magnetic nanocomposite (mSiO2@Fe3O4 @Au) was synthesized using ethylene glycol (EG) as template at two different ratios of EG: TEOS of 0.1 and 0.6. The chemistry, morphology, optical and magnetic properties of the obtained nanocomposites were characterized by Fourier Transform (FTIR), Scanning Electron Microscopy (SEM), Transverse Electron Microscopy (TEM), Atomic Force Microscopy (AFM), X-ray Diffractometry (XRD), Vibrating Sample Magnetometry (VSM) and UV-Vis absorption spectroscopy. The mean diameter of amino-functionalized SiO2 NPs was measured 70 nm. The range of porosity ranged from 10 to 100 nm, with larger distribution of pore size of less than 20 nm. The average radius of pores on SiO2 NPs calculated by BJH method is approximately 15.5 nm. Magnetic nanoparticles (MNPs) with the average diameter of 34 nm were synthesized and then coated by AuNPs with an average size of 25 nm synthesized via a two-step process of dative and reduction method. The average size distribution of mSiO2@Fe3O4@Au nanocomposite was measured about 157 nm. The nanocomposite exhibited a significant red-shift in surface plasmon resonance wavelength (λSPR ≈ 800 nm), which coincides with NIR biomedical applications.

Different artificial sweeteners were studied in blood medium as electrolyte by cyclic voltammetric technique using modified glassy carbon electrode with carbon nanotubes to determine the diffusion coefficient for the redox current peaks of artificial sweetener by Randles-Sevcik equation. It was determined the viscosity of the blood medium after the addition of the artificial sweetener to find the relationship between the viscosity and the diffusion of sweetener ions in blood medium and reach to the electrode. The high viscosity of blood and addition of the sweetener compound which causes impedes of diffusion the ions for redox current of the reaction on the surface of the sensor. So, the results of diffusion coefficient values depended on the viscosity of blood medium. Sorbitol compound has a higher viscosity in blood medium with lower diffusion coefficient values of redox current peaks and mannitol has lower viscosity in the series of the sweetener compounds in blood medium with high values of diffusion coefficient for the redox current peaks.

In this article are presented the results of 113 women of reproductive age study. The control group included 45 healthy women (the age range 22-47 years) who had no urogenital, endocrine system diseases or surgical inter-vention, no earlier than 9 months after the last birth and at least 3 months of regular menstrual cycles. The main group: 68 patients (the age range 24-48 years) suffering from secondary infertility, who subsequently as a result of an in-depth study found a tuberculosis lesion of the uterus. The main criteria for diagnosis were three times sowing of menstrual blood during one menstruation for bacteriological examination for the presence of my-cobacterium tuberculosis, bacterioscopic and bacteriological examination of the secretion of the cervix on the microflora and mycobacterium tubercu-losis. The aim of the study was to study the value of ultrasonic elas-tography with a shear wave elastography (SWE) in tuberculosis lesions of the uterus at patients with secondary infertility. Complex ultrasound studies of the uterus and appendages using the ultrasound elastography and SWE were performed on the Aixplorer (Supersonic Imagine, France). Based on the data obtained by us using the technology of elastography and SWE, stiffness values for unchanged endometrium, uterine myometrium in healthy women of reproductive age are established. The significant differences in the stiffness of the endometrium and myometrium of the uterus body of healthy women of reproductive age and patients with tuberculosis lesion of the uterus, revealed by us, indicate the expediency of using SWE with elas-tometry in the study of patients suffering from secondary infertility.